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studied the mutational spectrum of TP53 in 572 breast cancers and found that luminal breast cancers were predominantly missense mutations, particularly A:T to G:C transitions, whereas basal breast cancers showed a higher incidence of truncating mutations [40]

By smoking one packet of cigarettes every day, a smoker is pouring a cupful of these tars into his or her lungs every year (225 grams on average)

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